Premier League players will be allowed to travel to red-list nations to represent their countries in this month's World Cup qualifiers - but only if they are fully vaccinated.
Players must adhere to a strict code of conduct regarding transport, close contacts, testing and bubbles.
They will have to quarantine in "bespoke facilities" for 10 days upon their arrival back in the UK.
They will be permitted to leave quarantine once a day to train or play.
"We have worked closely with football authorities to achieve an outcome that balances the interests of both club and country while maintaining the highest levels of public health and safety," said a government spokesperson.
"Our best defence against the virus is vaccination and these new measures will allow fully vaccinated players to fulfil their international duties in the safest, most practical way possible, while allowing them to train and play with their clubs as early as possible upon their return."
The UK government has relaxed Covid-19 regulations after the problems it caused during the September international break.
On that occasion, the Premier League decided not to release players, prompting a clash with football's world governing body Fifa, which had demanded individuals be allowed to travel and play.
Aston Villa and Tottenham did allow their Argentina internationals to represent their country for their World Cup qualifiers in South America.
However, it led to farcical scenes at the Brazil v Argentina game in Sao Paulo where the match was abandoned after five minutes when Brazilian health officials came on to the pitch to stop play, saying Argentina's four England-based players had to quarantine.
They returned via Croatia to avoid having to quarantine when arriving back in the UK.
In addition,
eight Nigeria internationals based in the UK missed their country's second September World Cup qualifier in Cape Verde, while other UK-based African players could also not report for international duty.
Argentina and
Brazil had already named Premier League players in their squads for October's qualifiers before the relaxation of the UK's quarantine rules for footballers.
Since Friday, Argentine nationals do not need to quarantine after arrival in the country from overseas, if they are vaccinated and test negative for Covid.
The Brazilian football federation, meanwhile, will have to reach a separate agreement with the country's health authority to exempt England-based players from quarantine on their arrival.
Currently, anyone travelling to Brazil from the UK must quarantine for 14 days when they arrive in the country.
Liverpool boss Jurgen Klopp has criticised the new UK plan, saying it is not "properly thought through".
"It's 10 days' quarantine, allowed to play the games, allowed to go to work, not allowed to live at home but don't need to live in a hotel chosen by any authorities and you can choose it yourself. Food has to be delivered in front of your room door. You're not allowed any visitors," he said.
"That would mean for the players after the international break that they go for 10-12 days with their national teams and then they go another 10 days into quarantine away from their families. That's 22 days and two weeks later there is the next international break.
"It doesn't sound to me like a real solution."
https://www.bbc.co.uk/sport/football/58753489
Luckily for Spurs this new agreement should help our South American players. They will still have to "quarantine" for 10 days on return but can leave their quarantine to play matches or to train during this time...not sure how that can be still described as quarantining but sure that's why others are in charge of the country. I couldn't come out with statements like that with a straight face
