The pending antibiotics disaster..

Spursex

Alert Team
Antibiotics: 'national threat' from steep rise in patients who are resistant to drugs

Health officials express concern after 600 reported cases of drugs failing because of resistant bacteria last year

Officials said the scale of such infections had become a matter of “national concern” with 600 cases reported last year - compared to just five in 2006

Officials said the scale of such infections had become a matter of “national concern” with 600 cases reported last year - compared to just five in 2006 Photo: ALAMY
Laura Donnelly

By Laura Donnelly, Health Editor

10:00PM GMT 06 Mar 2014

A steep rise in the number of patients who do not respond to antibiotic treatment risks causing a “national health threat”, NHS officials have warned.

Experts say the explosion in the use of antibiotics in the Western world to treat common ailments could become a “catastrophic threat” because increasingly bacteria have become resistant to the drugs, so they do not work when they are really needed.

Officials said the scale of such infections had become a matter of “national concern” with 600 cases reported last year, compared with just five in 2006.

Dame Sally Davies, the chief medical officer for England has previously warned that the threat hanging over the country is equal to that of terrorism.

On Thursday she called for urgent action to reduce the number of antibiotics being prescribed, and improve hygiene in hospitals to prevent the spread of resistant bacteria.


Figures from Public Health England have documented the rise in a group of infections called carbapenemase-producing Enterobacteriaceae (CPE) — which are resistant even to antibiotics that are normally given as a “last resort” because nothing else works.

Patients in this situation still sometimes respond to other drugs, but it can be difficult to find the right treatment in time.

Experts said that the situation was particularly worrying in London and in Manchester, where two NHS trusts, Central Manchester Foundation Trust and University Hospitals South Manchester have each reported at least 100 cases in the past five years.

The report says medical staff need to be trained so they are more aware of the risks of prescribing unnecessary antibiotics, and to improve hygiene to ensure cases of CPE did not spread.

It also says that staff need to be alert to the increased risk of infection from patients from high-risk overseas countries, which include Bangladesh, China, Cyprus, Greece, India, Italy, Malta, Pakistan, Taiwan, Turkey, the United States and all countries in North Africa and the Middle East.

Dr Paul Cosford, PHE’s medical director said: “We need to act swiftly to avoid getting into the situation which has been seen in some other countries, such as Greece, Israel and the United States, where there is significant resistance. “These infections are already causing national concern due to the observed increasing trends in the number of infections, outbreaks and clusters across England.

“We now have a window of opportunity, if we act quickly and decisively, to address this very real public health threat and prevent widespread problems by minimising the negative impact of these organisms.”

He said that, while many countries with such problems were tackling them effectively, Greece was among several where the problem was “out of control”.

Dame Sally said: “Antibiotic resistance poses a real threat to our ability to treat diseases.

“Although there has been an increase in this strain of bacteria, the new toolkit will ensure that hospitals are well placed to detect, manage and control any cases.

“Systems of monitoring for resistant bacteria are essential in safeguarding the effect of our antibiotics.”

She said many of the drugs were being used unnecessarily for mild illnesses that should not be treated with antibiotics — helping to create resistance.
 
How much of this is part blamed on over use of prescription drugs as people take things for every ache or sniff? add cleaning products hat sanitise 99.9% of germs etc and we are becoming soft as our immune systems no longer have to work as hard. whatever happened to eating a bit of dirt?
 
oxfordspur - 7/3/2014 10:53

How much of this is part blamed on over use of prescription drugs as people take things for every ache or sniff? add cleaning products hat sanitise 99.9% of germs etc and we are becoming soft as our immune systems no longer have to work as hard. whatever happened to eating a bit of dirt?

One of the biggest badly understood contributory factors that still isn't clear is the effect that the mass use of anti-biotics in promoting growth in sheep/cattle/pigs has.

Immunity from effective drugs as widespread as it is with a huge class of antibiotics now has to occur as an evolution over a long period of time, and in recent years resistance has grown dramatically, which funny enough has coincided with a huge increase in use in meat production.

At this rate within 20 years we won't have a single effective antibiotic left of the current crop.
 
I am preparing by watching the box set of Walking Dead. I am ready for you mother fckin dead walkers. I have also been watching The Road recently and think this may be a possibly nicer way for things to pan out. I am legend was a bit harder to believe but still quite interesting. Anyhow, once it kicks off i have my escape route planned, i know which shops i will be raiding for supplies and what motor i will be using to get there. I am gonna then live in peace at the top of a mountain shooting anyone that appoaches.
 
The Road - a laugh every page. Great Book

I think humans may be coming to an end. WW3 anybody? Russia nukes us all over Ukraine could do it

If you consider certain animals you see signs of species plain giving-up. Pandas for example - what the eat (bamboo) is insufficient diet making them listless. They try to climb but fall down and injure themselves.

And then there's Panda sex. They are completely hopeless! females come into season for about 10 minutes whilst the males suddenly find their left foot fascinating.

Take TAnsy beetles they have wings but dont fly to the tansy bushes to feed and end up eating each other. Result? not many around same as the pandas. Basically like the Aztecs (or was it the Incas?) they've given up.

Same for us - we let the city and banks lose us billions and pay themselves big bonuses. How mental is that? Press the button Vladimir, lets get it over with
 
ST2 - 7/3/2014 12:20

The Road - a laugh every page. Great Book

I think humans may be coming to an end. WW3 anybody? Russia nukes us all over Ukraine could do it

If you consider certain animals you see signs of species plain giving-up. Pandas for example - what the eat (bamboo) is insufficient diet making them listless. They try to climb but fall down and injure themselves.

And then there's Panda sex. They are completely hopeless! females come into season for about 10 minutes whilst the males suddenly find their left foot fascinating.

Take TAnsy beetles they have wings but dont fly to the tansy bushes to feed and end up eating each other. Result? not many around same as the pandas. Basically like the Aztecs (or was it the Incas?) they've given up.

Same for us - we let the city and banks lose us billions and pay themselves big bonuses. How mental is that? Press the button Vladimir, lets get it over with

Hold on!...Hold on!. Just a wee minute here. You feckin wait with that there button Vladimir.

I've bloody read and wrote copious amounts second guessing who the next bloody manager is going to be. Give a guy the chance to see who the feck it is!.
 
Another reason resistance is building is people not finishing their anti-biotic courses. They stop taking them as soon as they start feeling better. Meaning that you now have a propotion of the original infection that has strengthened itself through courses of the drug that are used to stop it. Pretty much microscopic Darwinism in 2-4 weeks.

Swear I read something about Russian alternatives that were highly effective during the cold war, when they could import pharmaceuticals. Totally blanked on what it was called.

Also doctors actively proscribing drugs in western countries that they knew, since their second biology course, would have no effect on the ailment.

Though as ex has said, use in livestock has accelerated the problem dramatically.

Though the Argentinian steak I had the other week was to die for...

 
ST2 - 7/3/2014 12:20

The Road - a laugh every page. Great Book

I think humans may be coming to an end. WW3 anybody? Russia nukes us all over Ukraine could do it

If you consider certain animals you see signs of species plain giving-up. Pandas for example - what the eat (bamboo) is insufficient diet making them listless. They try to climb but fall down and injure themselves.

And then there's Panda sex. They are completely hopeless! females come into season for about 10 minutes whilst the males suddenly find their left foot fascinating.

Take TAnsy beetles they have wings but dont fly to the tansy bushes to feed and end up eating each other. Result? not many around same as the pandas. Basically like the Aztecs (or was it the Incas?) they've given up.

Same for us - we let the city and banks lose us billions and pay themselves big bonuses. How mental is that? Press the button Vladimir, lets get it over with

I quite enjoyed reading this as, although very cynical, for the most part is true. My particular area of interest is the devolution of man. We peaked in most things in around the 70s. My strong belief is the human race is getting more and more stupid.

Mediocrity is celebrated these days. Kids are given awards for losing and it's funny to fail or to not care. Right wing politics is making its biggest come back in years through significant public discontent across the world. They are garnering support from the ill-educated and those adrift from faith in the current establishments. Civil unrest grows. Those of you down south may not see it, when I visit a lot of my old watering holes I can taste hate in the air.

For a humorous music video see:
http://youtu.be/m8fm3Z7jgWM
 
zzz - 27/5/2014 22:46

Another reason resistance is building is people not finishing their anti-biotic courses. They stop taking them as soon as they start feeling better. Meaning that you now have a propotion of the original infection that has strengthened itself through courses of the drug that are used to stop it. Pretty much microscopic Darwinism in 2-4 weeks.

Swear I read something about Russian alternatives that were highly effective during the cold war, when they could import pharmaceuticals. Totally blanked on what it was called.

Also doctors actively proscribing drugs in western countries that they knew, since their second biology course, would have no effect on the ailment.

Though as ex has said, use in livestock has accelerated the problem dramatically.

Though the Argentinian steak I had the other week was to die for...

I think you're referring to pharges or bacteriophages as some might better know them as. And you're right, the old Soviet Union used them extensively, supposedly with great success (although few claims were accurately verified), and even recently the old ex-soviet countries have started new/old centres such as the Eliava phage research institute to 'sell' these cures to (primarily) Americans that US doctors say they just can't effectively treat anymore.

A better hope is PPMOs, which is a whole new approach to the problem of fighting infections.

Bacteria’s new worst enemy may be a peptide-conjugated phosphorodiamidate morpholino oligomer, or PPMO. These lab-synthesized forms of DNA or RNA can silence specific genetic targets, and researchers say they function better than a standard antibiotic without the risk of bacteria becoming resistant to them.

Researchers tested PPMOs against infections in animals caused by two strains of Acinetobacter, which is affecting overseas US troops (shagging sheep!!??). Researchers say the PPMOs performed better than broad-spectrum antibiotics against A. baumannii, which can cause respiratory infections and sepsis and can be deadly to people with a weakened immune system.

Unlike antibiotics, which attack a bacteria cell’s function and can cause other side effects, PPMOs disrupt the bacteria’s genes. Issues of toxicity need to be addressed in further testing before PPMOs can be used in humans, the researchers said.

“The mechanism that PPMOs use to kill bacteria is revolutionary,” lead author Bruce Geller, a microbiology professor at Oregon State, said in a statement. “Molecular medicine is the way of the future.”

The research was published in the latest issue of The Journal of Infectious Diseases.
 
Only a 100 years ago the average age was what 30-40? The human body isn't really designed to live for 70 plus years.

We over use antibiotics. Any little sniffle you get put on drugs. Drugs is the easy option with GP's because most are fecking clueless.
 
'RD's' right. Doctors hand out antibiotics too much. People need to develop their immune systems. It was stated many years ago that we are becoming too frequent in the use of antibacterial soaps etc and live too clean lives. It was said that the reason asthma and other illnesses are increasing is because kids don't get their hands in soil enough and build up their natural resistance to bacteria. Most of these 'wipes' being used (kitchen wipes etc) are antibacterial.

OK, I took action myself on this front in a 'community' situation where as the manager of a large comprehensive school, I installed 'hole in the wall' automatic hand washing units in all the pupil toilets to avoid pupils having to touch the taps etc and to get rid of hand towels and I then installed antibacterial soap in them. This was to prevent spread of diseases like shigella, e'coli etc which had visited the area on occasions. But this was purely an action on behalf of the community to prevent the spread of communicable diseases which the school could be a natural centre for. The point I'm making is that we often do this in areas simply for that reason and rightly so but I'm all in favour of people getting their hands dirty from an early age, that's the natural way of things.

I do notice that the NHS locally is cutting down on prescribing anti-biotics and it will pay off in the long run I'm sure but what bothers me is that the strains of virus etc are becoming immune to the antibiotics and those new strains will need a new remedy.

Maybe the answer in the future will be to provide some sort of 'over the counter' testing kit to find out what we are suffering from. That may be a tall order but it is surely a very desirable thing to have in terms of finding out quickly what's wrong with us and cutting down NHS costs etc. Who knows what may be the next breakthrough in science? We need to be positive though and less in expectation of disaster.